COOLIEF* Cooled RF for Chronic Knee Pain

14 million+ people in the US suffer from knee osteoarthritis

Knee osteoarthritis (OA), the most common form of arthritis in the knee, occurs when the joint cartilage gradually degrades. Healthy cartilage provides lubrication and shock absorption for the joint. As it degrades, patients can experience painful bone-on-bone rubbing. Knee OA is a chronic condition that poses unique treatment challenges.1 While some patients believe surgery is the only effective knee OA treatment, non-surgical options are a less invasive and increasingly integral part of the treatment algorithm.

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Limitations of Conventional Management Options

Pharmacological therapy

    • NSAIDS are associated with serious side effects such as bleeding and GI ulcers2
    • Opioids are not recommended as they have a limited duration and a variety of associated risks3,4
Non-surgical Interventions

  • Local injections require multiple doses and can have limited effectiveness and clinical durability5
Surgical interventions

  • 50-80% of knee OA patients are either not ready or not suited for total knee arthroplasty (TKA)6

Advantages of Using COOLIEF* Cooled Radiofrequency

COOLIEF* Cooled RF can bridge the gap between short-term pain relief treatments and TKA by providing a minimally invasive, non-opioid procedure for OA knee pain.

Specifically designed to treat complex anatomy of variable nerve courses, COOLIEF* Cooled RF uses water-cooled technology that enables more RF energy to safely deactivate pain-transmitting sensory nerves. This creates a larger, spherical lesion that distally projects 45% or greater beyond the probe’s tip, allowing physicians to approach the target nerve from any angle.

  • Demonstrates up to 24 months pain relief with improved physical function and a reduction in opioid medication usage.
  • Clinically proven to provide pain relief for patients experiencing pain post-TKA
  • First and only radiofrequency treatment FDA-cleared for OA knee pain

Clinical Data Supporting the Use of COOLIEF* Cooled RF

Two large Level I randomized clinical studies have demonstrated the extended clinical durability of COOLIEF* Cooled RF and it’s superiority to intra-articular steroid injections (IAS) and hyaluronic acid (HA) in the management of knee OA. COOLIEF* Cooled RF is a safe, effective and consistent treatment, one which fills the treatment gap between short-term pain relief treatments and total knee replacement.

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  1. Mora JC, Przkora R, Cruz-Almeida Y. Knee osteoarthritis: pathophysiology and current treatment modalities. J Pain Res. 2018;11:2189-2196.
  2. Choi WJ, Hwang SJ, Song JG, et al. Radiofrequency treatment relieves chronic knee osteoarthritis pain: a double-blind randomized controlled trial. J Pain. 2011;152(3):481–487.
  3. Trang T, Al-Hasani R, Salvemini D, et al. Pain and poppies: the good, the bad, and the ugly of opioid analgesics. J Neurosci. 2015;35(41):13879-13888.
  4. Bennell KL, Hinman RS. A review of the clinical evidence for exercise in osteoarthritis of the hip and knee. J Sci Med Sport. 2011;14(1):4-9.
  5. Hepper CT, Halvorson JJ, Duncan ST, et al. The efficacy and duration of intra-articular corticosteroid injection for knee osteoarthritis: a systematic review of level I studies. J Am Acad Orthop Surg. 2009;17(10):638-646.
  6. OA Pain Landscape & Patient Journey: Research Results. KS&R, 2015. Page 11. Available upon request.